Role of OmpA in the multidrug resistance phenotype of Acinetobacter baumannii.
نویسندگان
چکیده
Acinetobacter baumannii has emerged as a nosocomial pathogen with an increased prevalence of multidrug-resistant strains. The role of the outer membrane protein A (OmpA) in antimicrobial resistance remains poorly understood. In this report, disruption of the ompA gene led to decreased MICs of chloramphenicol, aztreonam, and nalidixic acid. We have characterized, for the first time, the contribution of OmpA in the antimicrobial resistance phenotype of A. baumannii.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 58 3 شماره
صفحات -
تاریخ انتشار 2014